Plasma ammonia levels in patients treated with valproic acid
نویسندگان
چکیده
10.4172/Neuropsychiatry.1000178 © 2017 pISSN 1758-2008 eISSN 1758-2016 Neuropsychiatry (London) (2017) 7(1), 42–47 42 1Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan †Author for correspondence: Prof. Reiji Yoshimura, Department of Psychiatry, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.; Tel: +81-93-691-7253, Fax: +81-93-692-4894, email: yoshi621@ med.uoeh-u.ac.jp Plasma ammonia levels in patients treated with valproic acid
منابع مشابه
Therapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State
Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...
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Blood carnitine and/or acetylcarnitine deficiencies are postulated in the literature as possible causes of higher ammonia levels. The aim of this study was to investigate if the use of valproic acid, the age of the patients, or certain central nervous system pathologies can cause carnitine and/or acetylcarnitine deficiency leading to increased ammonia levels. Three groups of patients were studi...
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Numerous cases of severe and life-threatening hyperammonemia (HA) related to the treatment of epileptic seizures with valproic acid (VPA) have been previously reported in the medical literature. The aim of this prospective, multicenter study was to verify the putative association between T1405 polymorphism and occurrence of VPA-induced HA in the cohort of 142 adult Caucasian patients with epile...
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The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA....
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